The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

在微创手术中，视频分析的手术工作流程分割是一个经过深入研究的主题。常规方法将其定义为多类分类问题，其中各个视频帧被归因于手术期标签。我们引入了一种新颖的加强学习公式，以用于离线相过渡检索。我们没有尝试对每个视频框架进行分类，而是确定每个相转换的时间戳。通过构造，我们的模型不会产生虚假和嘈杂的相变，而是相邻的相位块。我们研究了该模型的两种不同配置。第一个不需要在视频中处理所有帧（在2个不同的应用程序中仅<60％和<20％的帧），而在最新的精度下略微产生结果。第二个配置处理所有视频帧，并以可比的计算成本优于最新技术。 We compare our method against the recent top-performing frame-based approaches TeCNO and Trans-SVNet on the public dataset Cholec80 and also on an in-house dataset of laparoscopic sacrocolpopexy.我们同时执行基于框架的（准确性，精度，召回和F1得分），也可以对我们的算法进行基于事件的（事件比率）评估。

在双胞胎输血综合征（TTTS）中，单座管胎盘中的异常血管吻合可能会在两个胎儿之间产生不均匀的流量。在当前的实践中，通过使用激光消融闭合异常吻合来对TTT进行手术治疗。该手术在最小的侵入性中依赖于胎儿镜检查。有限的视野使吻合术识别成为外科医生的具有挑战性的任务。为了应对这一挑战，我们提出了一个基于学习的框架，用于视野扩展的体内胎儿镜框架注册。该框架的新颖性依赖于基于学习的关键点提案网络以及基于胎儿镜图像细分和（ii）不一致的同符的编码策略（i）无关的关键点。我们在来自6个不同女性的6个TTT手术的6个术中序列的数据集中验证了我们的框架，这是根据最新的最新算法状态，该算法依赖于胎盘血管的分割。与艺术的状态相比，提出的框架的性能更高，为稳健的马赛克在TTTS手术期间提供背景意识铺平了道路。

超声检查的胎儿生长评估是基于一些生物特征测量，这些测量是手动进行并相对于预期的妊娠年龄进行的。可靠的生物特征估计取决于标准超声平面中地标的精确检测。手动注释可能是耗时的和依赖操作员的任务，并且可能导致高测量可变性。现有的自动胎儿生物特征法的方法依赖于初始自动胎儿结构分割，然后是几何标记检测。但是，分割注释是耗时的，可能是不准确的，具有里程碑意义的检测需要开发特定于测量的几何方法。本文描述了Biometrynet，这是一个克服这些局限性的胎儿生物特征估计的端到端地标回归框架。它包括一种新型的动态定向测定（DOD）方法，用于在网络训练过程中执行测量特定方向的一致性。 DOD可降低网络训练中的变异性，提高标志性的定位精度，从而产生准确且健壮的生物特征测量。为了验证我们的方法，我们组装了一个来自1,829名受试者的3,398张超声图像的数据集，这些受试者在三个具有七个不同超声设备的临床部位收购。在两个独立数据集上的三个不同生物识别测量值的比较和交叉验证表明，生物元网络是稳健的，并且产生准确的测量结果，其误差低于临床上允许的误差，优于其他现有的自动化生物测定估计方法。代码可从https://github.com/netanellavisdris/fetalbiometry获得。

胎儿镜检查激光​​光凝是一种广泛采用的方法，用于治疗双胞胎输血综合征（TTTS）。该过程涉及光凝病理吻合术以调节双胞胎之间的血液交换。由于观点有限，胎儿镜的可操作性差，可见性差和照明的可变性，因此该程序尤其具有挑战性。这些挑战可能导致手术时间增加和消融不完全。计算机辅助干预措施（CAI）可以通过识别场景中的关键结构并通过视频马赛克来扩展胎儿镜观景领域，从而为外科医生提供决策支持和背景意识。由于缺乏设计，开发和测试CAI算法的高质量数据，该领域的研究受到了阻碍。通过作为MICCAI2021内窥镜视觉挑战组织的胎儿镜胎盘胎盘分割和注册（FETREG2021）挑战，我们发布了第一个Largescale Multencentre TTTS数据集，用于开发广义和可靠的语义分割和视频摩擦质量algorithms。对于这一挑战，我们发布了一个2060张图像的数据集，该数据集是从18个体内TTTS胎儿镜检查程序和18个简短视频剪辑的船只，工具，胎儿和背景类别的像素通道。七个团队参与了这一挑战，他们的模型性能在一个看不见的测试数据集中评估了658个从6个胎儿镜程序和6个短剪辑的图像的图像。这项挑战为创建通用解决方案提供了用于胎儿镜面场景的理解和摩西式解决方案的机会。在本文中，我们介绍了FETREG2021挑战的发现，以及报告TTTS胎儿镜检查中CAI的详细文献综述。通过这一挑战，它的分析和多中心胎儿镜数据的发布，我们为该领域的未来研究提供了基准。

背景：荧光血管造影表现出非常有希望的结果，可以通过允许外科医生选择最佳灌注组织来减少吻合泄漏。但是，由于存在不同外科医生之间的显着差异，因此对荧光信号的主观解释仍然阻碍了该技术的广泛应用。我们的目的是开发一种人工智能算法，以基于术中荧光血管造影数据将结肠组织分类为“灌注”或“不灌注”。方法：在第三纪转介中心的荧光血管造影视频数据集中对具有重新结构结构的分类模型进行了训练。与结肠的荧光和非荧光段相对应的框架用于训练分类算法。进行了使用训练集未使用的患者的框架进行验证，包括使用相同的设备和使用其他相机收集的数据收集的数据。计算了性能指标，并用于进一步分析输出。根据组织分类确定了决策边界。结果：卷积神经网络已成功地对790名患者进行了1790帧的培训，并在14例患者的24帧中进行了验证。训练集的准确性为100％，验证集为80％。训练集的召回和精度分别为100％和100％，验证集分别为68.8％和91.7％。结论：具有高度准确性的术中荧光血管造影的自动分类是可能的，并且允许自动决策边界识别。这将使外科医生能够标准化荧光血管造影技术。基于Web的应用程序可用于部署该算法。

Machine learning models are typically evaluated by computing similarity with reference annotations and trained by maximizing similarity with such. Especially in the bio-medical domain, annotations are subjective and suffer from low inter- and intra-rater reliability. Since annotations only reflect the annotation entity's interpretation of the real world, this can lead to sub-optimal predictions even though the model achieves high similarity scores. Here, the theoretical concept of Peak Ground Truth (PGT) is introduced. PGT marks the point beyond which an increase in similarity with the reference annotation stops translating to better Real World Model Performance (RWMP). Additionally, a quantitative technique to approximate PGT by computing inter- and intra-rater reliability is proposed. Finally, three categories of PGT-aware strategies to evaluate and improve model performance are reviewed.

We test grip strength and shock absorption properties of various granular material in granular jamming robotic components. The granular material comprises a range of natural, manufactured, and 3D printed material encompassing a wide range of shapes, sizes, and Shore hardness. Two main experiments are considered, both representing compelling use cases for granular jamming in soft robotics. The first experiment measures grip strength (retention force measured in Newtons) when we fill a latex balloon with the chosen grain type and use it as a granular jamming gripper to pick up a range of test objects. The second experiment measures shock absorption properties recorded by an Inertial Measurement Unit which is suspended in an envelope of granular material and dropped from a set height. Our results highlight a range of shape, size and softness effects, including that grain deformability is a key determinant of grip strength, and interestingly, that larger grain sizes in 3D printed grains create better shock absorbing materials.

Accurate uncertainty measurement is a key step to building robust and reliable machine learning systems. Conformal prediction is a distribution-free uncertainty quantification algorithm popular for its ease of implementation, statistical coverage guarantees, and versatility for underlying forecasters. However, existing conformal prediction algorithms for time series are limited to single-step prediction without considering the temporal dependency. In this paper we propose a Copula Conformal Prediction algorithm for multivariate, multi-step Time Series forecasting, CopulaCPTS. On several synthetic and real-world multivariate time series datasets, we show that CopulaCPTS produces more calibrated and sharp confidence intervals for multi-step prediction tasks than existing techniques.

For conceptual design, engineers rely on conventional iterative (often manual) techniques. Emerging parametric models facilitate design space exploration based on quantifiable performance metrics, yet remain time-consuming and computationally expensive. Pure optimisation methods, however, ignore qualitative aspects (e.g. aesthetics or construction methods). This paper provides a performance-driven design exploration framework to augment the human designer through a Conditional Variational Autoencoder (CVAE), which serves as forward performance predictor for given design features as well as an inverse design feature predictor conditioned on a set of performance requests. The CVAE is trained on 18'000 synthetically generated instances of a pedestrian bridge in Switzerland. Sensitivity analysis is employed for explainability and informing designers about (i) relations of the model between features and/or performances and (ii) structural improvements under user-defined objectives. A case study proved our framework's potential to serve as a future co-pilot for conceptual design studies of pedestrian bridges and beyond.